MOLECULAR ANALYSIS OF NSP4 CODING GENE OF PORCINE ROTAVIRUS IN BRAZIL

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Analysis of NSP4 Gene and Its Association with Genotyping of Rotavirus Group A in Stool Samples

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Molecular characterization of the NSP4 gene of human group A rotavirus samples from the West Central region of Brazil.

Nonstructural protein 4 (NSP4), encoded by group A rotavirus genome segment 10, is a multifunctional protein and the first recognized virus-encoded enterotoxin. The NSP4 gene has been sequenced, and five distinct genetic groups have been described: genotypes A-E. NSP4 genotypes A, B, and C have been detected in humans. In this study, the NSP4-encoding gene of human rotavirus strains of differen...

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Analysis of NSP4 Gene and Its Association with Genotyping of Rotavirus Group A in Stool Samples

Background Non-structural protein 4 (NSP4) is a critical protein for rotavirus (RV) replication and assembly. This protein has multiple domains and motifs that predispose its function and activity. NSP4 has a sequence divergence in human and animal RVs. Recently, 14 genotypes (E1-E14) of NSP4 have been identified, and E1 and E2 have been shown to be the most common genotypes in human. Methods...

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ژورنال

عنوان ژورنال: Ars Veterinaria

سال: 2015

ISSN: 2175-0106,0102-6380

DOI: 10.15361/2175-0106.2015v31n1p42-49